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In vitro efficacy of a novel potassium oxalate hydrogel for dentin hypersensitivity
Author(s) -
Varoni Elena M.,
Zuccheri Tommaso,
Carletta Andrea,
Palazzo Barbara,
Cochis Andrea,
Colonna Martino,
Rimondini Lia
Publication year - 2017
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/eos.12334
Subject(s) - dentin hypersensitivity , dentin , potassium , dentinal tubule , smear layer , chemistry , permeability (electromagnetism) , oxalate , nuclear chemistry , materials science , biomedical engineering , chemical engineering , dentistry , composite material , biochemistry , inorganic chemistry , medicine , organic chemistry , membrane , engineering
A novel potassium oxalate‐based hydrogel is proposed for treating dentin hypersensitivity and this study evaluates its in vitro performance as a remineralizing, desensitizing agent. Etched disks of human dentin were treated for 10 or 20 min using the test hydrogel, to mimic a professional application with dental mouth guards. Dentin disks were evaluated in terms of permeability indexes in a fluid‐filled system, the surface morphology was assessed by scanning electron microscopy, and the structural properties were studied using X‐ray diffraction analysis. The potassium oxalate hydrogel significantly reduced dentin permeability, in a time‐dependent manner, and occluded most of the patent dentinal tubules via crystal precipitation, forming a remineralized layer. After hydrogel treatments, an acid solution (pH 4.2) was applied to the disks for 30 s, or 1, 2, or 5 min, in order to reproduce a plaque‐like oral acidity, and further analysis showed a good resistance of the remineralized layer to the acid challenge. The potassium oxalate‐based hydrogel showed a better performance over commercially available products and artificial saliva, appearing a promising candidate for the treatment of dentin hypersensitivity.