Premium
In vivo evaluation of the effects of hydraulic calcium silicate dental cements on plasma and liver aluminium levels in rats
Author(s) -
Demirkaya Kadriye,
Can Demirdöğen Birsen,
Öncel Torun Zeynep,
Erdem Onur,
Çetinkaya Serdar,
Akay Cemal
Publication year - 2016
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/eos.12238
Subject(s) - mineral trioxide aggregate , dentistry , in vivo , chemistry , calcium , medicine , nuclear chemistry , biology , microbiology and biotechnology , organic chemistry
Our aim was to test whether the presence of three hydraulic calcium silicate dental cements – MTA Angelus, MTA Fillapex, and Theracal LC – in the dental extraction socket of an in vivo model, would affect the levels of aluminium (Al) in the plasma and liver. Following anesthesia, the right upper incisor of each male Wistar albino rat was extracted and polyethylene tubes filled with MTA Angelus, MTA Fillapex, or Theracal LC were inserted into the depth of the extraction socket and gingival tissue was sutured. The rats were killed 7, 30, or 60 d after the operation. Blood and liver samples were obtained from the rats before they were killed, and the levels of Al were measured by atomic absorption spectrometry. Plasma Al levels were higher in the rats in which the mineral trioxide aggregate (MTA) cements were implanted, especially MTA Angelus and MTA Fillapex, compared with control rats. In liver samples, however, the differences in Al level were not statistically significant. Our results show that Al might have been released into the circulation from the three dental cements tested, especially MTA Angelus and MTA Fillapex. Further research should be carried out on the possible biological effects of Al liberated from dental cements.