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Expression of CD 163, interleukin‐10, and interferon‐gamma in oral squamous cell carcinoma: mutual relationships and prognostic implications
Author(s) -
Wang Shan,
Sun Miao,
Gu Chuanwen,
Wang Xiaolong,
Chen Dong,
Zhao Eryang,
Jiao Xiaohui,
Zheng Jinhua
Publication year - 2014
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/eos.12131
Subject(s) - immunohistochemistry , medicine , stage (stratigraphy) , basal cell , interferon gamma , interferon , metastasis , lymph node metastasis , cancer research , interleukin , pathology , cytokine , immunology , biology , cancer , paleontology
Tumor‐associated macrophages ( TAM s) and their associated inflammatory cytokines represent the major inflammatory component of the stroma of many tumors and can affect prognosis in the case of neoplasms. The objective of this study was to determine the prognostic significance of CD 163 + cells, interleukin‐10 ( IL ‐10), and interferon‐gamma ( IFN ‐ γ ) in oral lesions associated with oral squamous cell carcinoma ( OSCC ). The levels of CD 163, IFN ‐ γ , and IL ‐10 in the tissue samples of 240 patients with OSCC and 58 patients with other oral lesions were assessed by immunohistochemistry. Individuals with low IFN ‐ γ levels, high IL ‐10 levels, and low CD 163 levels were of special concern with respect to OSCC progression. We found that high levels of CD 163, or a combination of low IFN ‐ γ levels, high IL ‐10 levels, and low CD 163 levels, were associated with poorer overall survival ( OS ). CD 163 + cells provide better predictive power for OS in comparison with traditional markers, such as clinical stage and lymph node metastasis. Therefore, CD 163 + cells may be effective prognostic predictors of OSCC . IL ‐10 may also indicate poor outcomes when IFN ‐ γ secretion is low and the cells are CD 163 − .