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Role of the MIR 146A polymorphism in the origin and progression of oral squamous cell carcinoma
Author(s) -
Palmieri Annalisa,
Carinci Francesco,
Martinelli Marcella,
Pezzetti Furio,
Girardi Ambra,
Cura Francesca,
Rubini Corrado,
Scapoli Luca
Publication year - 2014
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/eos.12121
Subject(s) - carcinogenesis , allele , biology , cancer research , tumor progression , cell , microrna , basal cell , gene , cell growth , carcinoma , genotype , single nucleotide polymorphism , pathology , medicine , genetics
Gene expression and cell behavior are regulated by several factors, including small non‐coding RNA s. Micro RNA s affecting cell growth, differentiation, and apoptosis are thought to play an important role in tumorigenesis. The levels of miR‐146 appear to be associated with cancer development and progression, including that of oral squamous cell carcinoma. The aim of this investigation was to ascertain whether the single nucleotide polymorphism, rs2910164, mapping in the MIR146A gene, has a role in oral squamous cell carcinoma progression. A genetic association study was performed with a sample set of 346 oral squamous cell carcinomas collected in Italy. Our data indicate that the rs2910164 polymorphism is not associated with tumor development. However, a slight increase in the frequency of the variant allele was observed in Stage II tumors. Further investigations are needed to verify a possible role of the variant allele or rs2910164 in oral squamous cell carcinoma progression.