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Novel in‐situ longitudinal model for the study of dentifrices on dental erosion–abrasion
Author(s) -
Hara Anderson T.,
Barlow Ashley P.,
Eckert George J.,
Zero Domenick T.
Publication year - 2014
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/eos.12108
Subject(s) - dentifrice , dentistry , enamel paint , regimen , fluoride , abrasion (mechanical) , medicine , crossover study , sodium fluoride , placebo , orthodontics , chemistry , materials science , composite material , inorganic chemistry , alternative medicine , pathology
A novel longitudinal erosion–abrasion in ‐ situ model was proposed. In an exploratory test (phase 1) toothbrushing effect was investigated using a parallel design, whereas in the main study (phases 1 + 2), a crossover design tested the effect of fluoride dentifrice. In phase 1, 16 subjects ( n = 5–6 subjects per group) wore partial dentures with enamel specimens for 28 d and adhered to one of the following treatment regimens: regimen A , erosion only; regimen B , erosion + toothbrushing with fluoride‐containing dentifrice [1,100 ppm of fluoride as sodium fluoride ( N a F )]; and regimen C , erosion + toothbrushing with placebo dentifrice (0 ppm fluoride). Erosion consisted of the exposure of specimens to grapefruit juice. In regimens B and C , toothbrushing was performed with the test dentifrices 5 min after erosion. For the main study a second phase was carried out in which subjects initially treated with regimen B were treated with regimen C , and vice versa (crossover, n = 11), repeating the same experimental protocol. Enamel wear was measured by optical profilometry at baseline and every 7 d thereafter. In the exploratory test (phase 1), no significant differences were observed among regimens at any of the study time‐points. In the main study (phases 1 + 2), higher enamel wear was observed for regimen C than for regimen B . A significant trend was observed for the increase of enamel wear over time. Fluoridated dentifrice reduced the development of erosive–abrasive lesions. The proposed longitudinal model provided adequate responses for erosion–abrasion frequency and fluoride effects.