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Bacterial markers vs. clinical markers to predict progression of chronic periodontitis: a 2‐yr prospective observational study
Author(s) -
Charalampakis Georgios,
Dahlén Gunnar,
Carlén Anette,
Leonhardt Åsa
Publication year - 2013
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/eos.12080
Subject(s) - periodontitis , bleeding on probing , chronic periodontitis , medicine , dentistry , prospective cohort study , gastroenterology
The aim of this study was to identify sites at risk for future progression, during 2 yr of maintenance, in patients with chronic periodontitis ( CP ), based on longitudinal clinical and microbiological monitoring. At baseline (2003), clinical and microbiological features were recorded in 50 patients with CP . Two microbial samples were obtained from each patient (one from a clinically healthy site and one from a periodontitis site) and these were analyzed using DNA – DNA hybridization involving 25 bacterial species. After non‐surgical periodontal therapy, clinical and microbiological re‐examinations were performed at the same or similar sites at 2 yr (2006) and 4 yr (2008) of maintenance. Plaque, bleeding on probing (BoP), and the number of sites with periodontitis (≥4 mm) and severe periodontitis (≥6 mm) all showed a significant decrease at 2 and 4 yr of maintenance after non‐surgical intervention. Checkerboard analysis revealed that various bacteria with a high colonization score (≥3) corroborated the clinical findings of pathology at 2003, 2006, and 2008. Different clusters of bacteria, not just the ‘red complex’, were able to predict progression of chronic periodontitis during 2 yr of maintenance (2006–2008). Therefore, quantified bacterial markers (reflecting bacterial load) and the clinical markers BoP and periodontal probing depth show comparable prediction of future disease condition.