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Characteristics of S treptococcus mutans genotypes and dental caries in children
Author(s) -
Cheon Kyounga,
Moser Stephen A.,
Wiener Howard W.,
Whiddon Jennifer,
Momeni Stephanie S.,
Ruby John D.,
Cutter Gary R.,
Childers Noel K.
Publication year - 2013
Publication title -
european journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.802
H-Index - 93
eISSN - 1600-0722
pISSN - 0909-8836
DOI - 10.1111/eos.12044
Subject(s) - genotype , early childhood caries , genotyping , streptococcus mutans , dentistry , medicine , biology , genetics , oral health , gene , bacteria
This longitudinal cohort study evaluated the diversity, commonality, and stability of S treptococcus mutans genotypes associated with dental caries history. Sixty‐seven 5‐ and 6‐yr‐old children, considered as being at high caries risk, had plaque collected from baseline through 36 months for S . mutans isolation and genotyping using repetitive extragenic palindromic‐ PCR (4,392 total isolates). Decayed, missing, or filled surfaces (dmfs (primary teeth)/ DMFS (secondary teeth)) for each child were recorded at baseline. At baseline, 18 distinct genotypes were found among 911 S . mutans isolates from 67 children (diversity), and 13 genotypes were shared by at least two children (commonality). The number of genotypes per individual was positively associated with the proportion of decayed surfaces (p‐ds) at baseline. Twenty‐four of the 39 children who were available at follow‐up visits maintained a predominant genotype for the follow‐up periods (stability) and this was negatively associated with the p‐ds. The observed diversity, commonality, and stability of S . mutans genotypes represent a pattern of dental caries epidemiology in this high‐caries‐risk community, which suggests that fewer decayed surfaces are significantly associated with lower diversity and higher stability of S . mutans genotypes.