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Risk of SARS‐CoV ‐2 infection, hospitalization, and death for COVID ‐19 in people with Parkinson disease or parkinsonism over a 15‐month period: A cohort study
Author(s) -
Zenesini Corrado,
Vignatelli Luca,
Belotti Laura Maria Beatrice,
Baccari Flavia,
CalandraBuonaura Giovanna,
Cortelli Pietro,
Descovich Carlo,
Giannini Giulia,
Guaraldi Pietro,
Guarino Maria,
Loddo Giuseppe,
Pantieri Roberta,
Perlangeli Vincenza,
Scaglione Cesa,
Stivanello Elisa,
Trombetti Susanna,
D'Alessandro Roberto,
Baldin Elisa,
ino Francesco
Publication year - 2022
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.15505
Subject(s) - medicine , hazard ratio , cohort , pandemic , cohort study , comorbidity , covid-19 , parkinsonism , population , disease , pediatrics , confidence interval , infectious disease (medical specialty) , environmental health
Background and purpose The patterns of long‐term risk of SARS‐CoV‐2 infection, hospitalization for COVID‐19, and related death are uncertain in people with Parkinson disease (PD) or parkinsonism (PS). The aim of the study was to quantify these risks compared to a control population cohort, during the period March 2020–May 2021, in Bologna, Northern Italy. Methods ParkLink Bologna cohort (759 PD, 192 PS) and controls (9226) anonymously matched (ratio = 1:10) for sex, age, district, and comorbidity were included. Data were analysed in the whole period and in the two different pandemic waves (March–May 2020 and October 2020–May 2021). Results Adjusted hazard ratio of SARS‐CoV‐2 infection was 1.3 (95% confidence interval [CI] = 1.04–1.7) in PD and 1.9 (95% CI = 1.3–2.8) in PS compared to the controls. The trend was detected in both the pandemic waves. Adjusted hazard ratio of hospitalization for COVID‐19 was 1.1 (95% CI = 0.8–1.7) in PD and 1.8 (95% CI = 0.97–3.1) in PS. A higher risk of hospital admission was detected in PS only in the first wave. The 30‐day mortality risk after hospitalization was higher ( p = 0.048) in PS (58%) than in PD (19%) and controls (26%). Conclusions Compared with controls, after adjustment for key covariates, people with PD and PS showed a higher risk of SARS‐CoV‐2 infection throughout the first 15 months of the pandemic. COVID‐19 hospitalization risk was increased only in people with PS and only during the first wave. This group of patients was burdened by a very high risk of death after infection and hospitalization.