Premium
Association of major blood lipids with post‐stroke dementia: A community‐based cohort study
Author(s) -
Yang Zhirong,
Edwards Duncan,
Burgess Stephen,
Brayne Carol,
Mant Jonathan
Publication year - 2022
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.15219
Subject(s) - medicine , dementia , hazard ratio , stroke (engine) , confidence interval , proportional hazards model , vascular dementia , blood lipids , cohort study , cohort , retrospective cohort study , cholesterol , disease , mechanical engineering , engineering
Background and purpose The roles of blood low‐density lipoprotein cholesterol (LDL‐C), high‐density lipoprotein cholesterol (HDL‐C) and triglycerides in the development of post‐stroke dementia remain uncertain. This study was to investigate their potential associations. Methods A retrospective cohort study was conducted using the Clinical Practice Research Datalink. Patients with first‐ever stroke but no prior dementia were followed up for 10 years. Cox regression was used to examine the association of baseline LDL‐C, HDL‐C and triglycerides with post‐stroke dementia. Results Amongst 63,959 stroke patients, 15,879 had complete baseline data and were included in our main analysis. 10.8% developed dementia during a median of 4.6 years of follow‐up. The adjusted hazard ratio of dementia for LDL‐C (per log mmol/l increase) was 1.29 (95% confidence interval [CI] 1.14–1.47), with a linear increasing trend ( p trend <0.001). The counterpart for triglycerides was 0.79 (95% CI 0.69–0.89), with a linear decreasing trend ( p trend <0.001). For HDL‐C, there was no association with dementia (adjusted hazard ratio 0.89, 95% CI 0.74–1.08) or a linear trend ( p trend = 0.22). Conclusions Blood lipids may affect the risk of post‐stroke dementia in different ways, with higher risk associated with LDL‐C, lower risk associated with triglycerides, and no association with HDL‐C.