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No evidence for a specific vitamin D deficit in benign paroxysmal positional vertigo
Author(s) -
Goldschagg Nicolina,
Teupser Daniel,
Feil Katharina,
Strupp Michael
Publication year - 2021
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.14980
Subject(s) - medicine , vestibular system , benign paroxysmal positional vertigo , vertigo , vestibular disorders , pediatrics , gastroenterology , audiology , surgery
Abstract Background and purpose The aim was to investigate whether there is a difference in serum 25‐hydroxyvitamin D (25(OH)D) concentration between patients with benign paroxysmal positional vertigo (BPPV), patients with other vestibular diseases and patients with other neurological non‐vestibular diseases presenting in a tertiary neurological academic outpatient clinic. Methods The serum 25(OH)D concentration was measured in 680 patients (368 male, mean age ± SD 58 ± 17 years, 661 Caucasian) without vitamin D supplementation. 158 patients had BPPV; 221 had other vestibular diseases (including 122 with peripheral vestibular disorders, such as unilateral vestibulopathy or Ménière's disease; 46 with central vestibular disorders, such as vestibular migraine or cerebellar dizziness; 53 with functional dizziness); and 301 patients with other neurological non‐vestibular diseases. Results There was no significant difference in the serum 25(OH)D concentration between patients with BPPV (mean ± SD 23.4 ± 9.4 ng/ml) and those with other vestibular disorders (24.9 ± 10.1 ng/ml, p = 0.324). Patients with other neurological disorders had even lower concentrations (21.4 ± 10.6 ng/ml) than patients with BPPV ( p < 0.005), patients with other vestibular disorders ( p < 0.005) and all patients with vestibular disorders (24.9 ± 10.1 ng/ml, p < 0.005). Conclusion Our analysis does not support the theory of a specific relationship between serum 25(OH)D concentration and the occurrence of BPPV or other vestibular disorders.