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Association of HMOX‐1 with sporadic Alzheimer’s disease in southern Han Chinese
Author(s) -
Zhang Bei,
Yu HongXiang,
Zhi Nan,
Cui Can,
Han YingYing,
Hu Min,
Shen Hao,
Bao Huan,
Li Gang
Publication year - 2021
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.14870
Subject(s) - medicine , confidence interval , odds ratio , demography , disease , association (psychology) , gerontology , bioinformatics , psychology , biology , sociology , psychotherapist
Abstract Background and purpose The aim of this study was to discover the associations between HMOX‐1 and Alzheimer's disease (AD). Methods A total of 500 AD patients and 500 healthy controls were recruited in this study. Polymer chain reaction was used. Results There was a statistically significant difference between AD patients and controls in both the dominant and recessive models of HMOX‐1 rs2071746 after adjustment for age, gender and education (dominant model: p = 0.047, odds ratio [OR] 1.34, 95% confidence interval [CI] 1.00–1.78, adjusted; recessive model: p = 0.049, OR 1.34, 95% CI 1.00–1.80, adjusted). There was also a trend for an association between the dominant model and late‐onset AD after adjustment for age, gender and education (dominant model: p = 0.084, OR 1.37, 95% CI 0.96–1.95, adjusted). Conclusions We found an association between the dominant and recessive models of HMOX1 rs2071746 and AD.