Premium
cnm ‐Positive Streptococcus mutans and diffusion‐weighted imaging hyperintensities in acute intracerebral hemorrhage
Author(s) -
Shiga Yuji,
Aoki Shiro,
Hosomi Naohisa,
Nomura Ryota,
Nakamori Masahiro,
Nezu Tomohisa,
Tachiyama Keisuke,
Kamimura Teppei,
Kinoshita Naoto,
Shimomura Ryo,
Hayashi Yuki,
Matsushima Hayato,
Imamura Eiji,
Ueno Hiroki,
Wakabayashi Shinichi,
Nakano Kazuhiko,
Kohriyama Tatsuo,
Maruyama Hirofumi
Publication year - 2021
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.14725
Subject(s) - hyperintensity , medicine , streptococcus mutans , intracerebral hemorrhage , magnetic resonance imaging , gastroenterology , radiology , bacteria , genetics , biology , subarachnoid hemorrhage
Background Strains of Streptococcus mutans expressing the cell surface collagen‐binding protein, Cnm, encoded by cnm ( cnm ‐positive S . mutans ), are associated with hypertensive intracerebral hemorrhage (ICH) and the occurrence of cerebral microbleeds (CMBs). Small diffusion‐weighted imaging (DWI) hyperintensities in patients with acute ICH are also associated with CMBs. However, the association between cnm ‐positive S . mutans and DWI hyperintensities is unclear. Hence, this study aimed to investigate the association between cnm ‐positive S. mutans and DWI hyperintensities in patients with acute ICH. Methods Patients with acute ICH were prospectively registered at three hospitals. Dental plaque specimens were collected within 4 days after admission, and cnm ‐positive S . mutans was detected using the polymerase chain reaction. Magnetic resonance imaging at 14 ± 5 days after admission was used to evaluate DWI hyperintensities and CMBs. Results A total of 197 patients were enrolled in this study. cnm ‐positive S . mutans was detected in 30 patients (15.2%), and DWI hyperintensities were observed in 56 patients (28.4%). Patients with cnm ‐positive S . mutans had a higher frequency of DWI hyperintensities (50.0% vs 24.6%; p = 0.008) and a higher number of CMBs (5.5 vs 1.5; p < 0.001) than those without cnm ‐positive S . mutans . Multivariable logistic analysis revealed that the presence of cnm ‐positive S . mutans was independently associated with DWI hyperintensities (OR 2.38; 95% CI 1.01–5.61; p = 0.047) after adjusting for several confounding factors. Conclusion This study found an association between the presence of cnm ‐positive S. mutans and DWI hyperintensities in patients with acute ICH.