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Prognostic value of plasma fibroblast growth factor 21 among patients with acute ischemic stroke
Author(s) -
Zheng Xiaowei,
Zhu Zhengbao,
Guo Daoxia,
Zhong Chongke,
Xu Tan,
Peng Yanbo,
Wang Aili,
Peng Hao,
Ju Zhong,
Geng Deqin,
Zhang Yonghong,
He Jiang
Publication year - 2021
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.14683
Subject(s) - medicine , modified rankin scale , odds ratio , stroke (engine) , confidence interval , fgf21 , fibroblast growth factor , risk factor , ischemic stroke , ischemia , receptor , mechanical engineering , engineering
Background and purpose To evaluate the association between plasma fibroblast growth factor 21 (FGF‐21) and clinical outcomes in patients with acute ischemic stroke. Methods A total of 3412 acute ischemic stroke patients from the China Antihypertensive Trial in Acute Ischemic Stroke with plasma FGF‐21 measurements were included in this analysis. The primary outcome was a combination of death or major disability (modified Rankin Scale score ≥3) within 1 year after stroke. Results During the 1‐year of follow‐up, 745 (21.83%) patients experienced the primary outcome; 550 had a major disability and 195 died. After multivariate adjustment, higher plasma FGF‐21 was significantly associated with increased risk of the primary outcome (odds ratio = 1.52, 95% confidence interval = 1.11–1.29). Each 1‐SD increase of log‐transformed FGF‐21 (0.67 pg/ml) was associated with 19%, 3%, and 33% increased risk of the primary outcome, major disability, and death, respectively. The addition of FGF‐21 to the conventional risk factors significantly improved prediction of the primary outcome in ischemic stroke patients (net reclassification index = 10.8%, p = 0.011; integrated discrimination improvement = 0.3%, p = 0.038). Conclusions Higher plasma FGF‐21 was associated with poor prognosis in acute ischemic stroke patients, suggesting that FGF‐21 may be a prognostic marker for ischemic stroke.