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Increased short‐ and long‐term mortality following infections in dementia: a nationwide registry‐based cohort study
Author(s) -
Janbek J.,
Taudorf L.,
Musaeus C. S.,
FrimodtMøller N.,
Laursen T. M.,
Waldemar G.
Publication year - 2021
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.14595
Subject(s) - dementia , medicine , poisson regression , confidence interval , cohort , cohort study , pediatrics , mortality rate , epidemiology , gerontology , demography , disease , population , environmental health , sociology
Background and purpose Mortality following infections in dementia has not yet been comprehensively explored. The aim of this cohort study was to investigate the short‐ and long‐term mortality following infections in dementia. Methods Follow‐up was from 1 January 2000 or the 65‐year birthday until death, immigration, or 31 December 2015. Exposure was incident dementia and a first infection. The outcome was all‐cause mortality. Mortality rate ratios (MRRs) were calculated using Poisson regression in 4 exposure groups (dementia yes/no, infection yes/no) by sex, infection site, and time since infection. Results 1,496,436 people were followed with 12,739,135 person‐years. MRR in dementia/infection was 6.52 (95% confidence interval: 6.43–6.60) and was increased for infections of all sites. Increased mortality was short term (30 days) and long term (10 years). Conclusions Increased mortality in people with dementia identifies them as a particularly vulnerable group that needs clinical attention.