Premium
Diffuse brain connectivity changes in Charcot–Marie–Tooth type 1a patients: a resting‐state functional magnetic resonance imaging study
Author(s) -
Pontillo G.,
Tozza S.,
Perillo T.,
Cocozza S.,
Dubbioso R.,
Severi D.,
Iodice R.,
Tedeschi E.,
Elefante A.,
Brunetti A.,
Manganelli F.,
Quarantelli M.
Publication year - 2021
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.14540
Subject(s) - functional magnetic resonance imaging , medicine , default mode network , resting state fmri , magnetic resonance imaging , cerebellum , neuroscience , visual cortex , salience (neuroscience) , audiology , psychology , radiology
Evidence was found of diffuse functional reorganization involving multiple large‐scale networks in the Charcot–Marie–Tooth disease type 1A (CMT1A) brain, independent of structural abnormalities and partially correlating with peripheral nerve damage and functional impairment. These results, using CMT1A patients as a possible model to explore brain modifications associated with peripheral nervous system pathology, may shed new light onto central nervous system physiopathology and its role in the development of clinical disability in peripheral neuropathies.