Premium
Brain imaging factors associated with progression of subcortical hyperintensities in CADASIL over 2‐year follow‐up
Author(s) -
Moreton F. C.,
Cullen B.,
Dickie D. A.,
Lopez Gonzalez R.,
Santosh C.,
Delles C.,
Muir K. W.
Publication year - 2021
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.14534
Subject(s) - cadasil , medicine , hyperintensity , leukoencephalopathy , cardiology , cerebral blood flow , stroke (engine) , magnetic resonance imaging , pathology , neuroimaging , brain size , radiology , psychiatry , mechanical engineering , engineering
Cerebral blood flow declined in a cohort of CADASIL patients, as measured with arterial spin labelling MRI over two years. Lower cerebral blood flow at baseline predicted progression of subcortical hyperintensities at follow up. CBF may have a role as a biomarker in therapeutic trials in CADASIL.