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PER2 C111G polymorphism, cognitive reserve and cognition in subjective cognitive decline and mild cognitive impairment: a 10‐year follow‐up study
Author(s) -
Bessi V.,
Giacomucci G.,
Mazzeo S.,
Bagnoli S.,
Padiglioni S.,
Balestrini J.,
Tomaiuolo G.,
Piaceri I.,
Carraro M.,
Bracco L.,
Sorbi S.,
Nacmias B.
Publication year - 2021
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.14518
Subject(s) - medicine , cognitive decline , neuropsychology , cognitive reserve , cognition , per2 , disease , oncology , cognitive impairment , psychiatry , dementia , clock , circadian rhythm , circadian clock
Clock genes have been implicated in sleep‐wake cycle alterations and neurodegenerative diseases, but the role of PER2 C111G on cognition and on the risk of development Alzheimer’s Disease (AD) has not been explored so far. In a population of subjective cognitive decline (SCD) and mild cognitive impairment (MCI), PER2 G carriers presented lower scores on cognitive reserve proxies than G non‐carriers; MCI PER2 G carriers had worse performance in tests assessing memory, executive function, language and visuo‐spatial abilities. PER2 seems to have a role in cognitive reserve and cognitive functions in SCD and MCI patients; nevertheless, further studies are needed to assess the role of PER2 C111G on the risk of progression to AD.