Premium
Colchicine for stroke prevention in patients with coronary artery disease: a systematic review and meta‐analysis
Author(s) -
Katsanos A. H.,
Palaiodimou L.,
Price C.,
Giannopoulos S.,
Lemmens R.,
Kosmidou M.,
Georgakis M. K.,
Weimar C.,
Kelly P. J.,
Tsivgoulis G.
Publication year - 2020
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.14198
Subject(s) - medicine , stroke (engine) , colchicine , randomized controlled trial , coronary artery disease , placebo , meta analysis , relative risk , confidence interval , surgery , cardiology , pathology , mechanical engineering , engineering , alternative medicine
Background and purpose Although clinical trials suggest that colchicine may reduce the risk of vascular events in patients with a history of coronary artery disease, its effect on the prevention of cerebrovascular events still remains unclear. Methods A systematic review and meta‐analysis was performed of all available randomized controlled trials (RCTs) reporting on incident strokes during the follow‐up of patients with a history of cardiovascular disease randomized to colchicine treatment or control (placebo or usual care). Results Four RCTs were identified, including a total of 5553 patients (mean age 61 years, 81% males), with a follow‐up ranging from 1 to 36 months. Colchicine treatment was associated with a significantly lower risk of incident stroke during follow‐up compared to control (risk ratio 0.31, 95% confidence interval 0.13–0.71), without heterogeneity across included studies ( I 2 = 0%). Based on the pooled incident stroke rate of control groups (0.9%) in the included RCTs, it was estimated that administration of low‐dose colchicine to 161 patients with coronary artery disease would prevent one stroke during a follow‐up of 23 months. Conclusion Colchicine treatment decreases stroke risk in patients with a history of coronary artery disease. The effect of colchicine in secondary stroke prevention is currently being evaluated in an ongoing RCT.