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Hemorrhagic transformation after stroke: inter‐ and intrarater agreement
Author(s) -
Guenego A.,
Lecler A.,
Raymond J.,
Sabben C.,
Khoury N.,
Premat K.,
Botta D.,
Boisseau W.,
Maïer B.,
Ciccio G.,
Redjem H.,
Smajda S.,
Ducroux C.,
Di Meglio L.,
Davy V.,
Olivot J. M.,
Wang A.,
Duplantier J.,
Roques M.,
Krystal S.,
Koskas P.,
Collin A.,
Ben Maacha M.,
Hamdani M.,
Zuber K.,
Blanc R.,
Piotin M.,
Fahed R.
Publication year - 2019
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.13859
Subject(s) - medicine , stroke (engine) , confidence interval , radiology , mechanical engineering , engineering
Background and purpose Hemorrhagic transformation (HT) is a complication of stroke that can occur spontaneously or after treatment. We aimed to assess the inter‐ and intrarater reliability of HT diagnosis. Methods Studies assessing the reliability of the European Cooperative Acute Stroke Study (ECASS) classification of HT or of the presence (yes/no) of HT were systematically reviewed. A total of 18 raters independently examined 30 post‐thrombectomy computed tomography scans selected from the Aspiration versus STEnt‐Retriever (ASTER) trial. They were asked whether there was HT (yes/no), what the ECASS classification of the particular scan (0/HI1/HI2/PH1/PH2) (HI indicates hemorrhagic infarctions and PH indicates parenchymal hematomas) was and whether they would prescribe an antiplatelet agent if it was otherwise indicated. Agreement was measured with Fleiss’ and Cohen's κ statistics. Results The systematic review yielded four studies involving few (≤3) raters with heterogeneous results. In our 18‐rater study, agreement for the presence of HT was moderate [ κ = 0.55; 95% confidence interval (CI), 0.41–0.68]. Agreement for ECASS classification was only fair for all five categories, but agreement improved to substantial ( κ = 0.72; 95% CI, 0.69–0.75) after dichotomizing the ECASS classification into 0/HI1/HI2/PH1 versus PH2. The inter‐rater agreement for the decision to reintroduce antiplatelet therapy was moderate for all raters, but substantial among vascular neurologists ( κ = 0.70; 95% CI, 0.57–0.84). Conclusion The ECASS classification may involve too many categories and the diagnosis of HT may not be easily replicable, except in the presence of a large parenchymal hematoma.