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Subclinical motor impairment assessed with an engineered glove correlates with magnetic resonance imaging tissue damage in radiologically isolated syndrome
Author(s) -
Bonzano L.,
Bove M.,
Sormani M. P.,
Stromillo M. L.,
Giorgio A.,
Amato M. P.,
Tacchino A.,
Mancardi G. L.,
De Stefano N.
Publication year - 2019
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.13789
Subject(s) - medicine , subclinical infection , fractional anisotropy , asymptomatic , magnetic resonance imaging , multiple sclerosis , white matter , diffusion mri , nuclear medicine , pathology , radiology , psychiatry
Background An engineered glove measuring finger motor performance previously showed ability to discriminate early‐stage multiple sclerosis ( MS ) patients from healthy controls ( HCs ). Radiologically isolated syndrome ( RIS ) classifies asymptomatic subjects with brain magnetic resonance imaging ( MRI ) abnormalities suggestive of multiple sclerosis. Methods Seventeen asymptomatic subjects with RIS and 17 HCs were assessed. They performed finger‐to‐thumb opposition sequences at their maximal velocity, metronome‐paced bimanual movements and conventional and diffusion tensor MRI . Results Subjects with RIS showed lower ( P = 0.005) maximal velocity and higher ( P = 0.006) bimanual coordination impairment than HCs . In RIS , bimanual coordination correlated with T2‐lesion volume, fractional anisotropy and radial diffusivity in the white matter. Conclusions These findings point out the relevance of fine hand measures as a robust marker of subclinical disability.