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Alcohol overuse and intracerebral hemorrhage: characteristics and long‐term outcome
Author(s) -
AvellanedaGómez C.,
Serra Martínez M.,
RodríguezCampello A.,
Ois Á.,
CuadradoGodia E.,
GiraltSteinhauer E.,
VivancoHidalgo R.,
JiménezConde J.,
GómezGonzález A.,
Ceballos Cerrajería P.,
Zabalza de Torres A.,
MolaCaminal M.,
SorianoTárraga C.,
Roquer J.
Publication year - 2018
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.13734
Subject(s) - medicine , intracerebral hemorrhage , modified rankin scale , odds ratio , confidence interval , stroke (engine) , surgery , ischemic stroke , subarachnoid hemorrhage , mechanical engineering , ischemia , engineering
Background and purpose Alcohol overuse ( AO u) is considered an important risk factor for spontaneous intracerebral hemorrhage ( ICH ). The clinical and outcome characteristics of these patients ( AO u‐ ICH ) are not well known. Methods All patients with ICH admitted to a single university tertiary stroke center were prospectively studied from May 2005 to May 2015. Demographic profiles, radiologic characteristics and clinical outcomes of patients with acute ICH and previous AOu (>40 g/day or >300 g/week) were analyzed. Results During the study period, 555 patients with spontaneous primary ICH met the inclusion criteria. A total of 81 patients (14.6%) reported AO u (24.3% of men vs. 3.1% of women; P < 0.0001; mean age, 63 years old for AOu vs. 74 years old for non‐AOu; P < 0.0001). Of the classic cardiovascular risk factors, only smoking was associated with AO u (63% vs. 12.2% of non‐ AO u; P < 0.0001). Initial severity and hematoma volume were similar in both groups, with no observed differences in stroke care or in‐hospital medical complications. Patients with AO u had worse outcome (modified Rankin Scale score, 3–6 points) than patients without AO u at 3 months [odds ratio ( OR ), 2.50; 95% confidence interval ( CI ), 1.32–4.75; P = 0.005] and 12 months ( OR , 2.47; 95% CI , 1.23–5.00; P = 0.011). A similar trend was observed at 5 years ( OR , 2.48; 95% CI , 0.96–6.39; P = 0.059). Conclusions Alcohol overuse was present in 14.6% of patients with ICH , who were predominantly male, smokers and a mean of 11 years younger than the non‐ AO u group. Despite a lack of differences in initial clinical severity, stroke care and early medical complications, patients with AO u had worse short‐ and long‐term outcomes.