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Tau uptake in agrammatic primary progressive aphasia with and without apraxia of speech
Author(s) -
Utianski R. L.,
Whitwell J. L.,
Schwarz C. G.,
Duffy J. R.,
Botha H.,
Clark H. M.,
Machulda M. M.,
Senjem M. L.,
Knopman D. S.,
Petersen R. C.,
Jack C. R.,
Lowe V. J.,
Josephs K. A.
Publication year - 2018
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.13733
Subject(s) - primary progressive aphasia , precentral gyrus , medicine , precuneus , apraxia , aphasia , middle frontal gyrus , neuroscience , superior frontal gyrus , positron emission tomography , nuclear medicine , audiology , psychology , magnetic resonance imaging , radiology , frontotemporal dementia , cognition , psychiatry , dementia , disease
Background and purpose The non‐fluent/agrammatic variant of primary progressive aphasia (ag PPA ) is a heterogeneous diagnosis wherein some individuals have apraxia of speech ( AOS ). When ag PPA includes AOS , a tauopathy is the likely underlying pathology. Recently, [18F] AV ‐1451 was developed for the in‐vivo assessment of tau. In this study, we compared patterns of tau tracer uptake in patients with ag PPA with and without AOS. Methods Nine patients with ag PPA (four without AOS ) underwent tau positron emission tomography imaging with [18F] AV ‐1451. Uptake of [18F] AV ‐1451 was assessed as cortical to cerebellar crus ratio (standard uptake value ratio) in cortical regions of interest measured using the MCALT atlas and compared voxel‐wise in SPM 12. Each patient was age‐ and sex‐matched to three controls. Results The ag PPA without AOS showed uptake in the left frontal and temporal lobes, whereas ag PPA with AOS showed uptake in the bilateral supplementary motor areas, frontal lobes, precuneus and precentral gyrus relative to controls. The left precentral gyrus had uptake in ag PPA with AOS relative to those without AOS . Conclusions This cross‐sectional study suggests that [18F] AV ‐1451 uptake in the precentral gyrus is implicated in AOS in ag PPA .