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Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3‐like 1 and neurofilament light chain
Author(s) -
Quintana E.,
Coll C.,
SalavedraPont J.,
MuñozSan Martín M.,
RoblesCedeño R.,
TomàsRoig J.,
Buxó M.,
MatuteBlanch C.,
Villar L. M.,
Montalban X.,
Comabella M.,
Perkal H.,
Gich J.,
RamióTorrentà L.
Publication year - 2018
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.13687
Subject(s) - medicine , cerebrospinal fluid , multiple sclerosis , cognition , clinically isolated syndrome , cognitive impairment , immunology , psychiatry
Background and purpose Chitinase 3‐like 1 ( CHI 3L1) and neurofilament light chain ( NF ‐L) are promising biomarkers of disability in multiple sclerosis ( MS ). However, their role in cognitive dysfunction remains elusive. Here, we aimed to correlate cerebrospinal fluid ( CSF ) levels of CHI 3L1 and NF ‐L with cognitive status in MS . Methods Fifty one recently diagnosed patients were cognitively evaluated and CSF was collected. Levels of CHI3L1 and NF‐L were determined by ELISA. Spearman's partial correlation coefficient was performed. Results After adjusting cognitive scores by age, anxiety and EDSS, association was detected between CHI3L1 levels and Trail Making Test A (r s = 0.348; p = 0.016) and between NF‐L levels and Word List Generation (r s = −0.324; p = 0.025). Conclusion High levels of CSF CHI 3L1 and NF ‐L are associated with cognitive impairment in the early phases of MS .