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Association between oxidized low‐density lipoprotein and cognitive impairment in patients with ischemic stroke
Author(s) -
Wang A.,
Liu J.,
Meng X.,
Li J.,
Wang H.,
Wang Y.,
Su Z.,
Zhang N.,
Dai L.,
Wang Y.,
Wang Y.
Publication year - 2018
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.13497
Subject(s) - medicine , confidence interval , confounding , logistic regression , odds ratio , cognitive impairment , stroke (engine) , bayesian multivariate linear regression , mini–mental state examination , linear regression , cardiology , disease , mechanical engineering , machine learning , computer science , engineering
Background and purpose The association between oxidized low‐density lipoprotein (ox LDL ) and cognitive impairment is unclear. This study aimed to investigate the potential association between ox LDL and cognitive impairment among patients with acute ischemic stroke. Methods We measured the levels of ox LDL and recorded the Mini‐Mental State Examination ( MMSE ) score in patients with acute ischemic stroke who were recruited from the Study of Oxidative Stress in Patients with Acute Ischemic Stroke. Cognitive impairment was defined as an MMSE score of <24. The association between ox LDL and cognitive impairment was assessed by multivariate logistic or linear regression analysis. Other clinical variables of interest were also studied. Results A total of 3726 patients [1287 (34.54%) female] were included in this study, with a mean age of 63.62 ± 11.96 years. After adjusting for potential confounders in our logistic regression model, each SD increase in ox LDL was associated with a 26% increase in the prevalence of cognitive impairment (odds radio, 1.26; 95% confidence interval, 1.13–1.39; P < 0.0001). Similarly, higher ox LDL was associated with lower MMSE scores, with a 0.56‐point decrease in MMSE score for every SD increase in ox LDL in a linear regression analysis ( β = −0.56; 95% confidence interval, −0.81 to −0.32; P < 0.0001). There were no significant interactions between ox LDL and age, sex or education levels for cognitive impairment (all interactions, P > 0.05). Conclusions Elevated levels of ox LDL were associated with a higher prevalence of cognitive impairment in patients with ischemic stroke.