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Epidemiological patterns of tick‐borne encephalitis in Lithuania and clinical features in adults in the light of the high incidence in recent years: a retrospective study
Author(s) -
Radzišauskienė D.,
Žagminas K.,
Ašoklienė L.,
Jasionis A.,
Mameniškienė R.,
Ambrozaitis A.,
Jančorienė L.,
Jatužis D.,
Petraitytė I.,
Mockienė E.
Publication year - 2018
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.13486
Subject(s) - medicine , incidence (geometry) , tick borne encephalitis , epidemiology , encephalitis , pediatrics , retrospective cohort study , virology , pathology , virus , physics , optics
Background and purpose Lithuania is one of the countries with the highest incidence of tick‐borne encephalitis ( TBE ) in Europe. The aim of this study was to describe the epidemiological patterns of TBE in Lithuania, and characterize clinical features in adults in the light of the high incidence in recent years. Methods Surveillance data available on the website of the Centre for Communicable Diseases and AIDS of Lithuania were used to describe the epidemiological patterns of TBE . The retrospective study included 712 patients hospitalized in the Centre for Infectious Diseases and the Centre for Neurology of Vilnius University in the years 2005–2014. Results Tick‐borne encephalitis incidence rates have been increasing by 8.5% per year for the 45‐year period from 1970 to 2014. The joinpoint model finds two joinpoints at 1991 and 1994, with a significant decrease of 8.4% per year ( P < 0.05) prior to the joinpoint at 1991, and a rise of 195.2% afterwards. TBE presented with meningoencephalitis in 556 cases (81.3%). A total of 129 patients (18%) had a severe case of the disease. The most common neurological signs were ataxia (579, 81.3%), meningeal signs (474, 66.5%) and tremor (338, 47.5%). Limb paresis was observed in 6.3% of patients. Five patients (0.7%) died, and 544 patients (76.7%) were discharged with sequelae. Conclusions Intensified efforts in promoting TBE vaccination will be needed in the light of the high incidence and expanded spatial distribution. Significant prognostic factors for severe cases of the disease were age above 61 and delayed immune response of specific immunoglobulin G.