Premium
Low clinical conversion rate in clinically isolated syndrome patients – diagnostic benefit of McDonald 2010 criteria?
Author(s) -
Rosenkranz S. C.,
Kaulen B.,
Neuhaus A.,
Siemonsen S.,
Köpke S.,
Daumer M.,
Stellmann J.P.,
Heesen C.
Publication year - 2018
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.13476
Subject(s) - medicine , multiple sclerosis , mcdonald criteria , clinically isolated syndrome , cohort , incidence (geometry) , diagnostic test , magnetic resonance imaging , pediatrics , radiology , psychiatry , physics , optics
Background and purpose New diagnostic criteria of multiple sclerosis ( MS ) increase the number of patients being diagnosed with MS whilst a substantial part might not convert to clinically definite MS ( CDMS ). The diagnostic accuracy of the McDonald 2005 and 2010 criteria for conversion to CDMS was evaluated in an unselected cohort of patients in whom an MS diagnostic work‐up was decided. Methods Clinical, magnetic resonance imaging and cerebrospinal fluid data were analysed for all patients who presented with symptoms suspicious for MS at the university based MS outpatient clinic between 2006 and 2010 ( n = 165). Results Follow‐up was available for 131 patients. During the mean follow‐up period of 2 years, 19% of patients developed CDMS whereas 64% of the patients fulfilling McDonald 2010 criteria did not convert to CDMS . Conclusion The low clinical conversion rate indicates that the new diagnostic criteria may increase the incidence of MS cases with a less active disease course.