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Atrial fibrillation is associated with cognitive decline in stroke‐free subjects: the Tromsø Study
Author(s) -
Tiwari S.,
Løchen M. L.,
Jacobsen B. K.,
Hopstock L. A.,
Nyrnes A.,
Njølstad I.,
Mathiesen E. B.,
Arntzen K. A.,
Ball J.,
Stewart S.,
Wilsgaard T.,
Schirmer H.
Publication year - 2017
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.13445
Subject(s) - medicine , atrial fibrillation , stroke (engine) , body mass index , physical therapy , depression (economics) , population , cognitive decline , cognition , digit symbol substitution test , prospective cohort study , cardiology , disease , psychiatry , dementia , mechanical engineering , alternative medicine , environmental health , pathology , engineering , economics , macroeconomics , placebo
Background and purpose Previous studies have shown associations between atrial fibrillation ( AF ) and cognitive decline. We investigated this association in a prospective population study, focusing on whether stroke risk factors modulated this association in stroke‐free women and men. Methods We included 4983 participants (57% women) from the fifth survey of the Tromsø Study (Tromsø 5, 2001), of whom 2491 also participated in the sixth survey (Tromsø 6, 2007–2008). Information about age, education, blood pressure, body mass index, lipids, smoking, coffee consumption, physical activity, depression, coronary and valvular heart disease, heart failure and diabetes was obtained at baseline. AF status was based on hospital records. The outcome was change in cognitive score from Tromsø 5 to Tromsø 6, measured by the verbal memory test, the digit–symbol coding test and the tapping test. Results Mean age at baseline was 65.4 years. The mean reduction in the tapping test scores was significantly larger in participants with AF (5.3 taps/10 s; 95% CI: 3.9, 6.7) compared with those without AF (3.8 taps/10 s; 95% CI: 3.5, 4.1). These estimates were unchanged when adjusted for other risk factors and were similar for both sexes. AF was not associated with change in the digit–symbol coding or the verbal memory tests. Conclusion Atrial fibrillation in stroke‐free participants was independently associated with cognitive decline as measured with the tapping test.