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Intracranial elastance is increased in idiopathic intracranial hypertension
Author(s) -
Chisholm J. T.,
Sudhakar P.,
Alhajeri A. N.,
Smith J. H.
Publication year - 2017
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.13410
Subject(s) - medicine , interquartile range , intracranial pressure , cohort , cerebrospinal fluid , hydrocephalus , cardiology , cerebrospinal fluid pressure , retrospective cohort study , surgery
Background and purpose To date, no pathophysiological model has sufficiently accounted for all the findings encountered in patients with idiopathic intracranial hypertension ( IIH ). Intracranial elastance is an index of volume‐buffering capacity known to play a role in certain disorders of cerebrospinal fluid ( CSF ) dynamics, which has not been previously investigated in relation to IIH patients. Methods This was a single‐center retrospective cohort study from 1 July 2011 to 1 July 2016. Values for opening pressure ( P O ), closing pressure ( P C ) and volume ( V ) of CSF removed were collected, as well as demographic and clinical covariates. Intracranial elastance ( E ) and pressure−volume index ( PVI ) were calculated according to established equations: E = ( P O − P C )/ V and PVI = V /log 10 ( P O / P C ), respectively. Those with an alternative central nervous system pathology, including meningitis, encephalitis and normal pressure hydrocephalus were excluded. Eligible patients were subdivided into two groups based on final diagnosis: a control group and an IIH group. Results In our cohort ( n = 49), a significant association of both E ( P < 0.0001) and PVI ( P = 0.005) with a diagnosis of IIH was observed. Median E was 0.45 [interquartile range ( IQR ) 0.29–0.63] in the control group and 1 ( IQR 0.59–1.29) in the IIH group, and median PVI was 98.07 ( IQR 59.92–135.86) in the control group and 64.1 ( IQR 42.4–91.7) in the IIH group. Neither E nor PVI were significantly associated with age, gender or body mass index. PVI was independent of opening pressure. Conclusions As calculated by clinically accessible indices, our study provides evidence that intracranial elastance is increased in IIH , reflecting a novel insight into disease pathogenesis.