Prevalence of Parkinson's disease: a population‐based study in Portugal

Background and purpose Portugal has been identified as one of the countries with a high prevalence of LRRK 2‐G2019S, considered to be the most frequent known cause of familial and sporadic Parkinson's disease ( PD ). The aim of this study was to evaluate the prevalence of PD in Portugal using a door‐to‐door methodology. Methods A cross‐sectional study was conducted in the Portuguese community‐dwelling population; that is, elderly people living in the community on their own, aged ≥50 years and resident in mainland Portugal, in two phases: (i) a questionnaire was applied to screen potential cases of PD ; and (ii) screened cases were evaluated by an expert in PD to confirm diagnosis. Results The adjusted prevalence of PD for the Portuguese community‐dwelling population aged ≥50 years was 0.24%. The estimated total number of cases of PD for the Portuguese population is 180/100 000 inhabitants. Conclusions The results of this study show that a geographical region with a high frequency of a causal mutation for PD does not automatically imply a high prevalence of patients with PD.