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5‐hydroxytryptamine1A receptor density in the hippocampus of patients with temporal lobe epilepsy is associated with disease duration
Author(s) -
Fonseca N. C.,
Joaquim H. P. G.,
Talib L. L.,
Vincentiis S.,
Gattaz W. F.,
Valente K. D.
Publication year - 2017
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.13252
Subject(s) - hippocampal sclerosis , temporal lobe , hippocampal formation , epilepsy , hippocampus , serotonergic , medicine , neuroscience , endocrinology , receptor , serotonin , psychology , psychiatry
Background and purpose To date, no study has evaluated the association between serotonin receptor density and clinical variables in patients with temporal lobe epilepsy caused by hippocampal sclerosis ( TLE ‐ HS ) using hippocampal tissue. We evaluated 5‐hydroxytryptamine1A receptor (5‐ HT 1 AR ) density in hippocampal tissue from patients with TLE ‐ HS . Methods We analyzed the hippocampal tissue of 34 patients with pharmacoresistant unilateral TLE ‐ HS . 5‐ HT 1 AR density was measured using semiquantitative western blotting. Results There was an association between higher density of 5‐ HT 1 AR and longer duration of epilepsy (Spearman correlation: P = 0.040; generalized linear model: P = 0.026). Conclusions This study demonstrated that hippocampal 5‐ HT 1 AR density is associated with epilepsy duration in patients with TLE ‐ HS . The authors postulate that this may represent a potential regulatory enhancement of endogenous serotonergic neurotransmission in response to prolonged and enduring epileptiform activity in the hippocampal tissue of patients with pharmacoresistant TLE ‐ HS .