z-logo
Premium
Serum 25‐hydroxyvitamin D deficiency predicts poor outcome amongst acute ischaemic stroke patients with low high density lipoprotein cholesterol
Author(s) -
Xu T.,
Zhong C.,
Peng Y.,
Chen C.S.,
Wang J.,
Ju Z.,
Li Q.,
Geng D.,
Sun Y.,
Zhang D.,
Zhang Y.,
Chen J.,
Xu T.,
Zhang Y.,
He J.
Publication year - 2016
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.13121
Subject(s) - medicine , ischaemic stroke , acute stroke , stroke (engine) , cardiology , cholesterol , ischemia , tissue plasminogen activator , mechanical engineering , engineering
Background and purpose Current observational studies indicate that a lower vitamin D level is associated with a higher risk of poor ischaemic stroke prognosis. Whether this association is affected by lipid levels is unclear. Our aim was to examine the effect of serum vitamin D especially its deficiency on the global outcome of ischaemic stroke stratified by individual lipid component level. Methods A total of 3181 ischaemic patients from China Antihypertensive Trial in Acute Ischaemic Stroke were included in this study and their baseline serum 25‐hydroxyvitamin D levels were tested. They were prospectively followed up for death, major disability and vascular events for 3 months after acute ischaemic stroke. A multivariable logistic model was used to evaluate the association between serum 25‐hydroxyvitamin D levels and clinical outcomes of ischaemic stroke in the 3‐month period of follow‐up in all patients and in different lipid‐level subgroups. Results Vitamin D deficiency was associated with poor clinical outcomes only in ischaemic stroke patients with high density lipoprotein cholesterol ( HDLC ) <1.04 mmol/l rather than all patients. The multivariable adjusted odds ratios (95% confidence intervals) of major disability and composite adverse events were 1.98 (1.08–3.63) and 2.24 (1.22–4.12), respectively. There was a significant interaction effect between vitamin D and HDLC levels on major disability and the composite outcome ( P for interaction < 0.05 for both). A significant linear trend existed between 25‐hydroxyvitamin D and risk of poor prognosis ( P = 0.03). Conclusions Vitamin D deficiency may be merely an independent risk factor of poor prognosis in ischaemic stroke patients with low HDLC level.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here