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Outcome of heparin‐treated patients with acute cerebral venous sinus thrombosis: influence of the temporal pattern of intracerebral haemorrhage
Author(s) -
Busch M. A.,
Hoffmann O.,
Einhäupl K. M.,
Masuhr F.
Publication year - 2016
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.13064
Subject(s) - medicine , cerebral venous sinus thrombosis , modified rankin scale , confidence interval , heparin , anesthesia , intracerebral hemorrhage , relative risk , complication , thrombosis , surgery , glasgow coma scale , ischemia , ischemic stroke
Background and purpose The influence of temporal patterns of intracerebral haemorrhage ( ICH ) on the outcome of heparin‐treated patients with cerebral venous sinus thrombosis ( CVST ) has not been examined systematically. Methods Temporal patterns of ICH and their influence on survival without disability (modified Rankin Scale score ≤1 point) at hospital discharge were examined in 141 consecutive hospital‐admitted patients with acute CVST who were treated with intravenous unfractionated heparin. Results Of all 141 patients (median age 40 years; 73% women), 59 (42%) had ICH at the time of diagnosis (early ICH ). Of these, seven (12%) subsequently had extension of ICH and 13 (22%) had additional ICH s at other locations (delayed ICH ). Of 82 patients without early ICH , nine (11%) later had delayed ICH . After a median hospital stay of 26 days, 107 patients (76%) were discharged without disability. Patients with early ICH were less likely to survive without disability until discharge than those without early ICH [63% vs. 85%; risk ratio ( RR ) 0.73; P = 0.005]. The association was attenuated after adjusting for age, sex and impaired consciousness on admission ( RR 0.83; P = 0.03). Taking temporal patterns of ICH into account, early ICH with subsequent complication (extension or delayed ICH ) had a larger influence on survival without disability ( RR 0.57; 95% confidence interval 0.35–0.95) than early ICH without complications ( RR 0.78; 95% confidence interval 0.67–0.91). Conclusions Heparin‐treated CVST patients were less likely to survive without disability when ICH was present on admission. This association may largely be driven by subsequent extension of haemorrhage or additionally occurring delayed haemorrhage.