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Is there a significant interaction effect between apolipoprotein E rs405509 T/T and ε4 genotypes on cognitive impairment and gray matter volume?
Author(s) -
Ma C.,
Zhang Y.,
Li X.,
Zhang J.,
Chen K.,
Liang Y.,
Chen Y.,
Liu Z.,
Zhang Z.
Publication year - 2016
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.13052
Subject(s) - apolipoprotein e , allele , cognition , medicine , fusiform gyrus , genotype , gray (unit) , psychology , neuroscience , psychiatry , genetics , biology , disease , nuclear medicine , gene
Background Evidence demonstrates that the T allele of the single‐nucleotide polymorphism rs405509 in the apolipoprotein E ( APOE ) promoter is a risk factor for Alzheimer's disease. However, it is unknown whether rs405509 T allele synergizes with the APOE ε4 allele in influencing cognition and brain structure. Methods We analyzed the interaction effect of the rs405509 T allele and the APOE ε4 allele on cognitive ability and brain gray matter volume among elderly people. The subjects were grouped into four groups according to APOE and rs405509 genotypes. Results Significant interaction effects were found between rs405509 and APOE on general mental status, memory and attention. Analysis of the whole brain gray matter showed a significantly positive interaction effect between rs405509and APOE on the right inferior temporal gyrus and right fusiform gyrus (alphasim correction P < 0.001). In addition, there was a significant relationship between cognitive ability and gray matter volume. Conclusions The data indicate that the APOE rs405509 T homozygote modulates the effect of APOE ε4 on both cognitive performance and brain gray matter structure.