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A European multicentre survey of impulse control behaviours in Parkinson's disease patients treated with short‐ and long‐acting dopamine agonists
Author(s) -
Rizos A.,
Sauerbier A.,
Antonini A.,
Weintraub D.,
MartinezMartin P.,
Kessel B.,
Henriksen T.,
FalupPecurariu C.,
Silverdale M.,
Durner G.,
Røkenes Karlsen K.,
Grilo M.,
Odin P.,
Chaudhuri K. Ray
Publication year - 2016
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.13034
Subject(s) - medicine , pramipexole , ropinirole , rotigotine , discontinuation , dopamine agonist , transdermal , confounding , parkinson's disease , disease , dopaminergic , dopamine , pharmacology
Background and purpose Impulse control disorders ( ICD s) in Parkinson's disease ( PD ) are associated primarily with dopamine agonist ( DA ) use. Comparative surveys of clinical occurrence of impulse control behaviours on longer acting/transdermal DA therapy across age ranges are lacking. The aim of this study was to assess the occurrence of ICD s in PD patients across several European centres treated with short‐ or long‐acting [ropinirole (ROP); pramipexole (PPX)] and transdermal [rotigotine skin patch ( RTG )] DAs, based on clinical survey as part of routine clinical care. Methods A survey based on medical records and clinical interviews of patients initiating or initiated on DA treatment (both short‐ and long‐acting, and transdermal) across a broad range of disease stages and age groups was performed. Results Four hundred and twenty‐five cases were included [mean age 68.3 years (range 37–90), mean duration of disease 7.5 years (range 0–37)]. ICD frequencies (as assessed by clinical interview) were significantly lower with RTG (4.9%; P < 0.05) compared with any other assessed DA s except for prolonged release PPX ( PPX ‐ PR ). The rate of ICD s for PPX ‐ PR (6.6%) was significantly lower than for immediate release PPX (PPX‐IR) (19.0%; P < 0.05). Discontinuation rates of DA therapy due to ICD s were low. Conclusion Our data suggest a relatively low rate of ICD s with long‐acting or transdermal DA s, however these preliminary observational data need to be confirmed with prospective studies controlling for possible confounding factors.