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Biological follow‐up in amyotrophic lateral sclerosis: decrease in creatinine levels and increase in ferritin levels predict poor prognosis
Author(s) -
Patin F.,
Corcia P.,
Madji Hounoum B.,
VeyratDurebex C.,
Respaud E.,
Piver E.,
Benzde Bretagne I.,
Vourc'h P.,
Andres C. R.,
Blasco H.
Publication year - 2015
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.12754
Subject(s) - amyotrophic lateral sclerosis , medicine , ferritin , creatinine , disease , oncology , multivariate analysis , biomarker , biochemistry , chemistry
Background and purpose Amyotrophic lateral sclerosis (ALS) is a fatal disorder of the motor neuron system, with a median survival of 2 to 4 years and a wide variety of prognosis. Thus, there is a critical need for diagnosis and prognosis biomarkers to improve the care of patients in routine practice. In this study, we aimed to determine prognostic value of routine biochemical markers in sporadic ALS (SALS). Methods We retrospectively collected clinical and biological data obtained during the systematic routine monitoring of 216 sporadic ALS patients. The main outcomes were disease duration and annual decline of Revised ALS Functional Rating Scale (ALSFRS‐R). Changes to these biological variables over time were assessed, in link with disease progression. Results We found that concentrations of creatinine ( P =0.0166) and ferritin ( P =0.0306) changed significantly during the progression of ALS. A reduction of creatinine levels and an increase of ferritin levels were associated with disease progression. Multivariate analysis showed that early variation of ferritin was an independent predictive factor of patient survival ( P =0.0048). Conclusion Changes to ferritin and creatinine levels with time are associated with ALS progression. This is the first study describing the changes to these biological variables during ALS progression.