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Retinal axonal loss in very early stages of multiple sclerosis
Author(s) -
Maghzi A.H.,
Graves J.,
Revirajan N.,
Spain R.,
Liu S.,
McCulloch C. E.,
Pelletier D.,
Green A. J.,
Waubant E.
Publication year - 2015
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.12722
Subject(s) - medicine , multiple sclerosis , nerve fiber layer , retinal , atrophy , white matter , magnetic resonance imaging , clinically isolated syndrome , ophthalmology , optical coherence tomography , confidence interval , neuroprotection , pathology , radiology , psychiatry
Background and purpose The lack of surrogates of clinical progression has limited the design of neuroprotection trials in multiple sclerosis ( MS ). Our aim was to study the association between time‐domain optical coherence tomography measures and clinical and magnetic resonance imaging outcomes in early MS . Methods Forty‐three relapsing−remitting MS patients within 1 year of onset were followed for up to 3 years. Results The peripapillary retinal nerve fiber layer ( RNFL ) decreased annually by 2 μm (95% confidence interval −3.89, −0.11; P = 0.038). The RNFL tended to be associated with normalized normal appearing white matter volume in cross‐sectional ( P = 0.08) and longitudinal analyses ( P = 0.06). Conclusions There is substantial RNFL loss even in very early MS . Our data suggest that retinal axonal atrophy is associated with atrophy in global white matter volume in early MS .
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