Premium
No impact of current therapeutic strategies on disease reactivation after natalizumab discontinuation: a comparative analysis of different approaches during the first year of natalizumab discontinuation
Author(s) -
Capobianco M.,
Sapio A.,
Malentacchi M.,
Malucchi S.,
Matta M.,
Sperli F.,
Bertolotto A.
Publication year - 2015
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.12487
Subject(s) - natalizumab , discontinuation , medicine , multiple sclerosis , disease , fingolimod , clinical disease , oncology , immunology
Background and purpose Natalizumab discontinuation induces the recurrence of multiple sclerosis disease activity: currently no therapeutic approach has been found able to abolish disease reactivation. Methods The recurrence of disease activity after natalizumab discontinuation was retrospectively evaluated in 79 patients who had been treated with immunomodulating agents, other first‐line therapies, fingolimod or not treated. Results No differences have been found in clinical or magnetic resonance imaging recurrence of disease activity amongst the groups. Interestingly, no disease reactivation was observed only in one patient treated for 6 months with monthly pulses of cyclophosphamide. Conclusion Disease modifying treatment or ‘no treatment’ is unable to abolish disease activity reactivation after natalizumab discontinuation.