Premium
Association between restless legs syndrome and migraine: a population‐based study
Author(s) -
Zanigni Stefano,
Giannini Giulia,
Melotti Roberto,
Pattaro Cristian,
Provini Federica,
Cevoli Sabina,
Facheris Maurizio F.,
Cortelli Pietro,
Pramstaller Peter P.
Publication year - 2014
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.12462
Subject(s) - medicine , migraine , restless legs syndrome , odds ratio , aura , anxiety , population , depression (economics) , confidence interval , migraine with aura , confounding , physical therapy , psychiatry , hospital anxiety and depression scale , pediatrics , neurology , environmental health , economics , macroeconomics
Background and purpose A higher prevalence of restless legs syndrome ( RLS ) in migraineurs has been reported in clinical samples and in two large‐scale clinical trials performed on healthcare workers but general population‐based studies on this topic are lacking. The aim of this study was to assess the association between migraine and RLS in an Italian rural adult population‐based setting. Methods The presence of migraine and RLS was assessed via a computer‐assisted personal interview and self‐administered questionnaires according to current diagnostic criteria in 1567 participants of a preliminary phase of an adult population‐based study performed in S outh T yrol, I taly. Results Migraineurs had an increased risk of having RLS also after adjustment for confounding factors such as age, sex, major depression, anxiety and sleep quality (odds ratio 1.79; confidence interval 1.00–3.19; P = 0.049). This association was not modified by aura status and possible causes of secondary RLS . RLS was not significantly associated with tension‐type headache. Conclusions R estless legs syndrome and migraine were associated in our rural adult population. This association could be explained by a possible shared pathogenic pathway which would implicate new management strategies of these two disorders.