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Association between metabolic syndrome and white matter lesions in middle‐aged and elderly patients
Author(s) -
Yin Z.G.,
Cui M.,
Zhou S.M.,
Yu M.M.,
Li R.,
Zhou H.D.
Publication year - 2014
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.12433
Subject(s) - medicine , metabolic syndrome , odds ratio , confidence interval , national cholesterol education program , hyperintensity , blood pressure , logistic regression , magnetic resonance imaging , obesity , radiology
Background and purpose Metabolic syndrome (MetS) has been reported to be associated with silent lacunar infarction, which is highly related to white matter lesions ( WML s). However, little is known about the relationship between MetS and the prevalence of WML s. The association between MetS, its components and WML s in middle‐aged and elderly patients was investigated. Methods Consecutive patients aged 50 years and older were prospectively enrolled in this study. All participants underwent magnetic resonance imaging scans to assess the presence and severity of WML s. The MetS was defined according to the updated National Cholesterol Education Program's Adult Treatment Panel III criteria. Multivariate logistic regression analyses were performed to examine the relationship between MetS, its components and WML s. Results A total of 852 patients were enrolled in the study. MetS was present in 38.4%. MetS was associated with an increased risk of periventricular WML s ( PVWML s) and deep WML s ( DWML s) after multivariable adjustment (odds ratio 3.21, 95% confidence interval 2.26–4.55 for PVWML s; odds ratio 2.93, 95% confidence interval 2.09–4.09 for DWML s). Amongst MetS components, elevated blood pressure, elevated fasting blood glucose and low high density lipoprotein cholesterol were associated with PVWML s, whilst elevated blood pressure and low high density lipoprotein cholesterol were related to DWML s. Conclusions Our findings demonstrate that MetS is associated with the prevalence of PVWML s and DWML s independent of other risk factors in middle‐aged and elderly patients. The association between MetS as a cluster and WML s was not driven by MetS components.