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Risk of accidental injuries amongst P arkinson disease patients
Author(s) -
Wang H.C.,
Lin C.C.,
Lau C.I.,
Chang A.,
Sung F.C.,
Kao C.H.
Publication year - 2014
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.12410
Subject(s) - medicine , hazard ratio , incidence (geometry) , accidental , confidence interval , spinal cord injury , cohort , head injury , surgery , spinal cord , physics , psychiatry , acoustics , optics
Background and purpose To investigate the spectrum and risks of accidental injuries ( AI s) amongst Parkinson disease ( PD ) patients. Methods The participants comprised PD patients aged 50 years and older who were initially diagnosed between 2000 and 2009, and a comparison group of non‐ PD patients. The incidence rates of accidental injury types amongst PD and non‐ PD patients were calculated; hazard ratios were calculated and adjusted for comorbidities, using 95% confidence intervals ( CI s) of developing such outcomes in PD patients. Results In total, 4046 PD patients and 16 184 non‐ PD patients were followed over time. The PD patients demonstrated the following incidence rates and hazard ratios in comparison to the control cohort for accidental injuries: all injuries, 19.78 per 100 person‐years (100 PY s), adjusted hazard ratio ( HR ) 1.30 (95% CI 1.24–1.36); head injury, 2.95 per 100 PY s, HR 1.88 (95% CI 1.64–2.15); bone fracture and dislocation, 4.61 per 100 PY s, HR 1.39 (95% CI 1.25–1.54); burns, 0.66 per 100 PY s, HR 1.01 (95% CI 0.78–1.32); injury to spinal cord, plexus and nerves, 0.15 per 100 PY s, HR 1.25 (95% CI 0.72–2.17); superficial injuries and contusions, 11.41 per 100 PY s, HR 1.20 (95% CI 1.12–1.27). The injury risk for the 69–79 years age group in PD compared with controls of the same age ( HR 1.38) was significantly higher compared with that of the 50–69 age groups in PD and controls ( HR 1.16). Conclusions Parkinson disease patients demonstrate a significantly elevated risk of developing all accidental injury types except burn injuries and injuries to spinal cord, plexus and nerves, compared with age‐matched controls. The risk increases as age increases.