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Cortical thickness and hippocampal shape in pure vascular mild cognitive impairment and dementia of subcortical type
Author(s) -
Kim H. J.,
Ye B. S.,
Yoon C. W.,
Noh Y.,
Kim G. H.,
Cho H.,
Jeon S.,
Lee J. M.,
Kim J.H.,
Seong J.K.,
Kim C.H.,
Choe Y. S.,
Lee K. H.,
Kim S. T.,
Kim J. S.,
Park S. E.,
Kim J.H.,
Chin J.,
Cho J.,
Kim C.,
Lee J. H.,
Weiner M. W.,
Na D. L.,
Seo S. W.
Publication year - 2014
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.12376
Subject(s) - dementia , medicine , atrophy , hippocampal formation , vascular dementia , cardiology , neuroscience , cognitive impairment , cognitive decline , posterior cingulate , cognition , audiology , pathology , psychology , disease
Background and purpose The progression pattern of brain structural changes in patients with isolated cerebrovascular disease ( CVD ) remains unclear. To investigate the role of isolated CVD in cognitive impairment patients, patterns of cortical thinning and hippocampal atrophy in pure subcortical vascular mild cognitive impairment (sv MCI ) and pure subcortical vascular dementia ( SV aD) patients were characterized. Methods Forty‐five patients with sv MCI and 46 patients with SV aD who were negative on Pittsburgh compound B (PiB) positron emission tomography imaging and 75 individuals with normal cognition ( NC ) were recruited. Results Compared with NC , patients with PiB(−) sv MCI exhibited frontal, language and retrieval type memory dysfunctions, which in patients with PiB(−) SV aD were further impaired and accompanied by visuospatial and recognition memory dysfunctions. Compared with NC , patients with PiB(−) sv MCI exhibited cortical thinning in the frontal, perisylvian, basal temporal and posterior cingulate regions. This atrophy was more prominent and extended further toward the lateral parietal and medial temporal regions in patients with PiB(−) SV aD. Compared with NC subjects, patients with PiB(−) sv MCI exhibited hippocampal shape deformities in the lateral body, whilst patients with PiB(−) SV aD exhibited additional deformities within the lateral head and inferior body. Conclusions Our findings suggest that patients with CVD in the absence of Alzheimer's disease pathology can be demented, showing cognitive impairment in multiple domains, which is consistent with the topography of cortical thinning and hippocampal shape deformity.