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Hemodynamic evidence linking cognitive deficits in clinically isolated syndrome to regional brain inflammation
Author(s) -
Papadaki E. Z.,
Simos P. G.,
Panou T.,
Mastorodemos V. C.,
Maris T. G.,
Karantanas A. H.,
Plaitakis A.
Publication year - 2014
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.12338
Subject(s) - corpus callosum , medicine , hemodynamics , white matter , cerebral blood flow , cardiology , verbal memory , multiple sclerosis , working memory , cognition , neuroscience , pathology , psychology , magnetic resonance imaging , radiology , psychiatry
Background and purpose To investigate the relation between hemodynamic measurements and memory function in patients with clinically isolated syndrome ( CIS ). Methods Forty CIS patients were administered tests of verbal short‐term/working memory and passage learning. Using dynamic susceptibility contrast MRI cerebral blood volume ( CBV ), cerebral blood flow and mean transit time values were estimated in 20 cerebral regions of interest, placed in normal appearing white matter ( NAWM ) and normal appearing deep gray matter structures, bilaterally. Results CIS patients showed significantly impaired scores on working memory and secondary verbal memory that correlated inversely with elevated CBV values in the left frontal and periventricular NAWM , thalamus, right caudate and corpus callosum. Conclusions Verbal memory in CIS correlates inversely with elevated CBV values of brain structures involved in memory. As these hemodynamic changes, detected in CIS , are indicative of inflammation, the observed cognitive disturbances may relate to widespread brain inflammatory processes that prevail in early multiple sclerosis.