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Epidemiology of chronic inflammatory neuropathies in southeast E ngland
Author(s) -
MahdiRogers M.,
Hughes R. A. C.
Publication year - 2014
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1111/ene.12190
Subject(s) - medicine , mismatch negativity , polyradiculoneuropathy , multifocal motor neuropathy , epidemiology , chronic inflammatory demyelinating polyneuropathy , population , disease , peripheral neuropathy , pediatrics , guillain barre syndrome , diabetes mellitus , immunology , psychiatry , environmental health , antibody , electroencephalography , endocrinology
Background and purpose There is little information about the prevalence and disease burden of chronic inflammatory demyelinating polyradiculoneuropathy ( CIDP ), multifocal motor neuropathy ( MMN ) and paraproteinaemic demyelinating neuropathy ( PDN ). Methods Multiple sources were used to study the prevalence and clinical features of these diseases in a southeast E ngland population of 3 557 352 people. Results The crude prevalences were as follows: CIDP , 2.84 (95% CI 2.31–3.45); MMN , 0.53 (95% CI 0.32–0.83); and PDN , 1.04 (95% CI 0.73–1.43) per 100 000 population. All three diseases were more common in men than in women. The peak decade of onset was older in those with CIDP (70–79 years) and PDN (70–79 years) than in those with MMN (50–59 years). Disability was greater in CIDP and PDN , with median (range) overall neuropathy limitations scores of 4 (0–8) and 4 (1–6), respectively, than in MMN , with a score of 2 (1–5). Conclusion The common forms of chronic inflammatory neuropathy cause a considerable disease burden in the community.