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Leukoaraiosis and acute ischemic stroke
Author(s) -
Tang Xiaojia,
Jiang Li,
Luo Yuhan,
Fan Hongyang,
Song Lilong,
Liu Peipei,
Chen Yingzhu
Publication year - 2021
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.15406
Subject(s) - leukoaraiosis , medicine , stroke (engine) , etiology , depression (economics) , disease , cardiology , acute stroke , infarction , neuroimaging , ischaemic stroke , myocardial infarction , physical therapy , intensive care medicine , ischemia , psychiatry , tissue plasminogen activator , dementia , mechanical engineering , engineering , economics , macroeconomics
Ischaemic stroke is characterized by high morbidity, high disability rate, high mortality and high recurrence rate, which can have a grave impact on the quality of life of the patients and consequently becomes an economic burden on their families and society. With the developments in imaging technology in recent years, patients with acute cerebral infarction are predominantly more likely to be diagnosed with leukoaraiosis (LA). LA is a common degenerative disease of the nervous system, which is related to cognitive decline, depression, abnormal gait, ischaemic stroke and atherosclerosis. The aetiology of LA is not clear and there is no gold standard for imaging assessment. Related studies have shown that LA has an adverse effect on the prognosis of cerebral infarction, but some experts have contrary beliefs. Hence, we undertook the present review of the literature on the mechanism and the effect of LA on the prognosis of patients with acute ischaemic stroke.