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Activity‐induced secretion of semaphorin 3A mediates learning
Author(s) -
JitsukiTakahashi Aoi,
Jitsuki Susumu,
Yamashita Naoya,
Kawamura Meiko,
Abe Manabu,
Sakimura Kenji,
Sano Akane,
Nakamura Fumio,
Goshima Yoshio,
Takahashi Takuya
Publication year - 2021
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.15210
Subject(s) - semaphorin , neuroscience , hebbian theory , synaptic plasticity , axon guidance , plexin , long term potentiation , metaplasticity , hippocampus , biology , pdz domain , microbiology and biotechnology , psychology , receptor , axon , computer science , biochemistry , machine learning , artificial neural network
The semaphorin family is a well‐characterized family of secreted or membrane‐bound proteins that are involved in activity‐independent neurodevelopmental processes, such as axon guidance, cell migration, and immune functions. Although semaphorins have recently been demonstrated to regulate activity‐dependent synaptic scaling, their roles in Hebbian synaptic plasticity as well as learning and memory remain poorly understood. Here, using a rodent model, we found that an inhibitory avoidance task, a hippocampus‐dependent contextual learning paradigm, increased secretion of semaphorin 3A in the hippocampus. Furthermore, the secreted semaphorin 3A in the hippocampus mediated contextual memory formation likely by driving AMPA receptors into hippocampal synapses via the neuropilin1–plexin A4–semaphorin receptor complex. This signaling process involves alteration of the phosphorylation status of collapsin response mediator protein 2, which has been characterized as a downstream molecule in semaphorin signaling. These findings implicate semaphorin family as a regulator of Hebbian synaptic plasticity and learning.