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Exploring the crosstalk of glycolysis and mitochondrial metabolism in psychiatric disorders and brain tumours
Author(s) -
Vlaikou AngelikiMaria,
Nussbaumer Markus,
Komini Chrysoula,
Lambrianidou Andromachi,
Konidaris Constantinos,
Trangas Theoni,
Filiou Michaela D.
Publication year - 2021
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.15057
Subject(s) - glycolysis , crosstalk , mitochondrion , oxidative phosphorylation , citric acid cycle , biology , phenotype , metabolic pathway , disease , metabolism , mitochondrial disease , neuroscience , bioinformatics , microbiology and biotechnology , medicine , mitochondrial dna , biochemistry , pathology , gene , physics , optics
Dysfunction of metabolic pathways characterises a plethora of common pathologies and has emerged as an underlying hallmark of disease phenotypes. Here, we focus on psychiatric disorders and brain tumours and explore changes in the interplay between glycolysis and mitochondrial energy metabolism in the brain. We discuss alterations in glycolysis versus core mitochondrial metabolic pathways, such as the tricarboxylic acid cycle and oxidative phosphorylation, in major psychiatric disorders and brain tumours. We investigate potential common patterns of altered mitochondrial metabolism in different brain regions and sample types and explore how changes in mitochondrial number, shape and morphology affect disease‐related manifestations. We also highlight the potential of pharmacologically targeting mitochondria to achieve therapeutic effects.