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Dopamine D4 receptor modulates inhibitory transmission in pallido‐pallidal terminals and regulates motor behavior
Author(s) -
Conde Rojas Israel,
AcostaGarcía Jackeline,
CaballeroFlorán Rene Nahum,
JijónLorenzo Rafael,
RecillasMorales Sergio,
AvalosFuentes José Arturo,
PazBermúdez Francisco,
LeyvaGómez Gerardo,
Cortés Hernán,
Florán Benjamín
Publication year - 2020
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.15020
Subject(s) - globus pallidus , neuroscience , medium spiny neuron , basal ganglia , dopamine , inhibitory postsynaptic potential , neurochemical , gabaergic , indirect pathway of movement , biology , neurotransmission , population , psychology , striatum , receptor , central nervous system , medicine , biochemistry , environmental health
Two major groups of terminals release GABA within the Globus pallidus; one group is constituted by projections from striatal neurons, while endings of the intranuclear collaterals form the other one. Each neurons' population expresses different subtypes of dopamine D2‐like receptors: D 2 R subtype is expressed by encephalin‐positive MSNs, while pallidal neurons express the D 4 R subtype. The D 2 R modulates the firing rate of striatal neurons and GABA release at their projection areas, while the D 4 R regulates Globus pallidus neurons excitability and GABA release at their projection areas. However, it is unknown if these receptors control GABA release at pallido‐pallidal collaterals and regulate motor behavior. Here, we present neurochemical evidence of protein content and binding of D 4 R in pallidal synaptosomes, control of [ 3 H] GABA release in pallidal slices of rat, electrophysiological evidence of the presence of D 4 R on pallidal recurrent collaterals in mouse slices, and turning behavior induced by D 4 R antagonist microinjected in amphetamine challenged rats. As in projection areas of pallidal neurons, GABAergic transmission in pallido‐pallidal recurrent synapses is under modulation of D 4 R, while the D 2 R subtype, as known, modulates striato‐pallidal projections. Also, as in projection areas, D 4 R contributes to control the motor activity differently than D 2 R. This study could help to understand the organization of intra‐pallidal circuitry.