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Leveraging sequence‐based faecal microbial community survey data to identify alterations in gut microbiota among patients with Parkinson's disease
Author(s) -
Ji Tianyi,
Huang Hongyan,
Liu Jiaxuan,
Peng Tian,
Zhou Xiazhu,
Tan Qin,
Yuan Jiaguo,
Hua Huan,
Ding Songtao,
Liu Handeng
Publication year - 2021
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.14952
Subject(s) - disease , microbiome , parkinson's disease , gut flora , metagenomics , biology , bacteroidetes , medicine , bioinformatics , immunology , genetics , 16s ribosomal rna , bacteria , gene
Parkinson's disease is a common degenerative disease of the elderly. Although the majority of studies have focused on the central nervous system (CNS) features of Parkinson's disease, recent findings suggest there is a functional link between the gut microbiome and the hallmarks of the disease. PubMed, Web of Science, EMBASE and other Chinese and English databases were searched for relevant literature. Studies on changes to intestinal microbiota in Parkinson's patients were retrieved and systematically reviewed. Quality filtering, clustering and species annotation were performed on 16s sequencing raw data from retrieved studies to achieve comparability across studies. Alpha‐diversity indices and a random effect model were used to analyse significantly altered microbiota. A total of nine studies were included in this retrospective analysis, four of which contained raw data. Alpha diversity was significantly different between control and Parkinson's disease patients in two of the four studies. Using the raw data from four individual studies, we observed differences in the phlya Bacteroidetes and Actinobacteria . Additionally, differences were observed between control and Parkinson's disease patients at the level of family ( Prevotellacaea and Lactobacillaceae ) and genus ( Bifidobacterium and Clostridium ). This study confirmed that changes in the microbiome are a consistent feature of Parkinson's disease patients and, therefore, may contribute to the onset of disease.