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Zebrafish models of impulsivity and impulse control disorders
Author(s) -
Abreu Murilo S.,
C. V. V. Giacomini Ana,
Genario Rafael,
Fontana Barbara D.,
Parker Matthew O.,
Marcon Leticia,
Scolari Naiara,
Bueno Barbara,
Demin Konstantin A.,
Galstyan David,
Kolesnikova Tatyana O.,
Amstislavskaya Tamara G.,
Zabegalov Konstantin N.,
Strekalova Tatyana,
Kalueff Allan V.
Publication year - 2020
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.14893
Subject(s) - impulsivity , zebrafish , danio , impulse control , psychology , neuroscience , bioinformatics , psychiatry , biology , genetics , gene
Impulse control disorders (ICDs) are characterized by generalized difficulty controlling emotions and behaviors. ICDs are a broad group of the central nervous system (CNS) disorders including conduct disorder, intermittent explosive, oppositional‐defiant disorder, antisocial personality disorder, kleptomania, pyromania and other illnesses. Although they all share a common feature (aberrant impulsivity), their pathobiology is complex and poorly understood. There are also currently no ICD‐specific therapies to treat these illnesses. Animal models are a valuable tool for studying ICD pathobiology and potential therapies. The zebrafish ( Danio rerio ) has become a useful model organism to study CNS disorders due to high genetic and physiological homology to mammals, and sensitivity to various pharmacological and genetic manipulations. Here, we summarize experimental models of impulsivity and ICD in zebrafish and highlight their growing translational significance. We also emphasize the need for further development of zebrafish ICD models to improve our understanding of their pathogenesis and to search for novel therapeutic treatments.