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Stria terminalis microstructure in humans predicts variability in orienting towards threat
Author(s) -
Koller Kristin,
Hatton Christopher M.,
Rogers Robert D.,
Rafal Robert D.
Publication year - 2019
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.14504
Subject(s) - stria terminalis , amygdala , psychology , neuroscience , anxiety , cognitive psychology , diffusion mri , medicine , magnetic resonance imaging , psychiatry , radiology
Abstract Current concepts of the extended amygdala posit that basolateral to central amygdala projections mediate fear‐conditioned autonomic alerting, whereas projections to the bed nucleus of the stria terminalis mediate sustained anxiety. Using diffusion tensor imaging tractography in humans, we show that microstructure of the stria terminalis correlates with an orienting bias towards threat in a saccade decision task, providing the first evidence that this circuit supports decisions guiding evaluation of threatening stimuli.